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| MultipleTestCorrection.java | 0% | 0% | 0% | 0% |
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package baseCode.math;
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import cern.colt.list.DoubleArrayList;
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/**
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* Methods for p-value correction of sets of hypothesis tests.
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* <p>
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* Copyright (c) 2004
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* </p>
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* <p>
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* Institution:: Columbia University
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* </p>
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*
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* @author Paul Pavlidis
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* @version $Id: MultipleTestCorrection.java,v 1.6 2004/07/27 03:18:57 pavlidis Exp $
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*/
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public class MultipleTestCorrection { |
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/**
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* Determine the Bonferroni pvalue threshold to maintain the family wise error rate (assuming pvalues are
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* independent).
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*
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* @param pvalues The pvalues
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* @param fwe The family wise error rate
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* @return The minimum pvalue that maintains the FWE
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*/
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public static double BonferroniCut( DoubleArrayList pvalues, double fwe ) { |
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int numpvals = pvalues.size();
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return fwe / numpvals;
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} |
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/**
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* Benjamini-Hochberg method. Determines the maximum p value to maintain the false discovery rate. (Assuming pvalues
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* are independent);
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*
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* @param pvalues list of pvalues. Need not be sorted.
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* @param fdr false discovery rate
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* @return The maximum pvalue that maintains the false discovery rate
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*/
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public static double BenjaminiHochbergCut( DoubleArrayList pvalues, |
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double fdr ) {
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int numpvals = pvalues.size();
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DoubleArrayList pvalcop = pvalues.copy(); |
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pvalcop.sort(); |
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pvalcop.reverse(); |
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int n = pvalcop.size();
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double thresh = fdr * n / numpvals;
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for ( int i = 0; i < n; i++ ) { |
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double p = pvalcop.get( i );
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if ( p < thresh ) {
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return p;
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} |
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} |
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return 0.0;
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} |
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} |
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